Author response: Circadian photoreceptor CRYPTOCHROME promotes wakefulness under short winter-like days via a GABAergic circuitry
Abstract
eLife AssessmentWinter months with short days are commonly associated with seasonal depression and hypersomnolence; the mechanisms behind this hypersomnolence however, remain unclear.Chen and colleagues identify a genetic basis for this phenomenon in the fly Drosophila -mutations in the circadian photoreceptor cryptochrome resulted in increased sleep under short photoperiods.These findings are valuable insights into the genetic mechanisms regulating sleep under short days.The data supporting the precise neurobiological basis of these effects however, remains incomplete.
Fields of Study & Subjects
Circadian rhythm and melatonin
Neurobiology and Insect Physiology Research
Sleep and Wakefulness Research
Publication details
- Journal / source
- eLife
- Publication date
- 10 March 2026
- Language
- EN