Reviewer #2 (Public Review): Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

eLife assessmentThe study presents important findings on the role of MSI2-HOXA9 translocation in chronic myeloid leukemia.The authors provide convincing evidence supporting the role of this translocation in leukemogenesis by using elegant mouse modeling and in vitro mechanistic studies.Consistent with the reviews, the studies can be strengthened with further murine and cell line experiments.Raw sequencing data for this manuscript are not available as the authors could not locate the files after moving institutions.Expression data for the RNA Seq data are available.