Author response: Mitochondrial protein carboxyl-terminal alanine-threonine tailing promotes human glioblastoma growth by regulating mitochondrial function

2026 Open access

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Authors: Bei Zhang, Ting Cai, Esha Reddy, Yuanna Wu, Isha Mondal, Yinglu Tang, Adaeze Scholastical Gbufor, Jerry Wang, Yawei Shen, Qing Liu, Raymond Sun, Winson S Ho
+2 more Rongze Olivia. Lu, Zhihao Wu
DOI: 10.7554/elife.99438.4.sa3
Cited by: 0

Abstract

The carboxyl-terminal alanine-threonine-tailed protein ATP5α helps glioblastoma mitochondria maintain a high membrane potential and keep the permeability transition pore closed, thereby promoting tumor growth and increasing resistance to apoptosis.

Fields of Study & Subjects

Mitochondrial Function and Pathology Cancer Hypoxia and Metabolism Cell death mechanisms and regulation

Publication details

Publication date
29 January 2026