Immune cell and cytokine profiles in a murine Aspergillus fumigatus extract sensitization model
Abstract
Fungal allergen sensitization is a clinically important gateway event in difficult-to-treat asthma, and Aspergillus fumigatus is among the most consequential aeroallergens associated with exacerbation risk and morbidity [1] .Sensitization programs T helper (Th) cell lineages, mobilizes innate effectors, and establishes downstream airway pathology.Traditionally, this is described as type 2 inflammation (driven by type 2 cytokines including interleukin-4 [IL-4], IL-5, and IL-13), with accumulating evidence that Th9/IL-9 contributes to mucus production, mast cell O r i g i n a l U n e d i t e d M a n u s c r i p t 7
Fields of Study & Subjects
Immunotoxicology and immune responses
T-cell and B-cell Immunology
vaccines and immunoinformatics approaches
Publication details
- Journal / source
- Journal of Biomedical Research
- Volume
- 40
- Issue
- 5
- Pages
- 562–562
- Publication date
- 1 January 2026
- Language
- EN