Relationship between blood pressure level and activity of renin-aldosterone axis in patients with essential hypertension—a retrospective study

Background: A study indicates that elevated aldosterone levels increase the risk of hypertension by 16%. This retrospective cohort study examines the relationship between blood pressure and renin-aldosterone levels in patients with essential hypertension (EH), aiming to elucidate the clinical features and risk factors of inappropriate hyperaldosteronism in Chinese individuals with essential hypertension. Methods: < 0.05 were included in the multivariate analysis, and the multiple linear regression analysis method was used for the multivariate analysis. The study assessed the relationship between the plasma renin activity (PRA), plasma aldosterone concentration (PAC), and the aldosterone/renin activity ratio (ARR) in patients with EH and their blood pressure levels. Results: < 0.05). Multiple linear stepwise regression indicated that higher aldosterone levels correlated with increased diastolic blood pressure. PAC increased by 3.66 ng/dL for every 10 mmHg of DBP. Conclusion: The increase in aldosterone levels is relatively common among EH patients in China. The increase in aldosterone levels is correlated with the elevation of diastolic blood pressure. The elevated aldosterone levels are an independent risk factor for the increase in diastolic blood pressure in EH patients.