A Case of Antinuclear Antibody-Negative Dermatomyositis with Interstitial Lung Disease
Abstract
BACKGROUND: Antinuclear antibody (ANA) is important for the diagnosis of autoimmune diseases. When ANA is positive, further specific autoantibody tests are needed to make a definite diagnosis. METHODS: This article reports a case of a patient with an autoimmune disease who had inconsistent results in the detection of antinuclear antibodies by indirect immunofluorescence assay (IIFA) and linear immunoblotting assay (LIA). RESULTS: This patient presented with negative ANA and positive anti-SSA/Ro52. CONCLUSIONS: IIF-ANA negative and LIA-ANAS positive exists in clinical tests. The combination of IIFA and LIA is important.
Fields of Study & Subjects
Inflammatory Myopathies and Dermatomyositis
Systemic Lupus Erythematosus Research
Systemic Sclerosis and Related Diseases
Publication details
- Journal / source
- Clinical Laboratory
- Volume
- 72
- Issue
- 01/2026
- Publication date
- 1 January 2026
- Language
- EN