Pregabalin Toxicity in Kidney Failure: A Medication Error With Neurological Consequences
Abstract
We present a case of pregabalin toxicity in a 50-year-old dialysis-dependent female, who presented with a one-day history of progressive weakness, lethargy, and gait disturbance. They were successfully treated with haemodialysis. The case is notable for the atypical toxidrome seen in kidney failure, which occurred after a community pharmacy error led to a single twelvefold-increased dose. It also demonstrates the role of the emergency department pharmacist, who was crucial in identifying the medication error. The report emphasises the importance of careful medication reconciliation, especially in patients with kidney failure. It also highlights the importance of considering gabapentinoid toxicity in any patient who presents with new, unexplained neurological symptoms.
Fields of Study & Subjects
Poisoning and overdose treatments
Pharmacovigilance and Adverse Drug Reactions
Pharmacological Effects and Toxicity Studies
Publication details
- Journal / source
- Cureus
- Publisher
- Springer Science and Business Media LLC
- Volume
- 18
- Issue
- 1
- Pages
- e100611–e100611
- Publication date
- 2 January 2026
- Language
- EN