Acquired Oral Hyperpigmentation: A Benign Finding or a Malignant Clue?

Cureus 2026 Open access

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Authors: Pablo Belmont Nava, Carol Estefanía Márquez Maldonado, Lucia Achell Nava, Dolores Maribel Arellano Vivero, Guadalupe Maldonado-Colín, Claudia Lucía Shoup Fierro
DOI: 10.7759/cureus.100640
Cited by: 0
References: 10

Abstract

Laugier-Hunziker syndrome (LHS) is a rare, acquired pigmentary disorder characterized by mucocutaneous hyperpigmentation, primarily affecting the oral mucosa and nails. We present a case of a 76-year-old male patient with extensive melanotic macules on the oral mucosa, lips, tongue, genitalia, and acral regions. Histopathological examination revealed basal layer hyperpigmentation and dermal melanophages. Systemic involvement was excluded through interdisciplinary evaluation. LHS, though benign, requires differentiation from syndromes with malignant potential, such as Peutz-Jeghers syndrome. This case underscores the importance of recognizing LHS to avoid unnecessary interventions and ensure appropriate patient reassurance.

Fields of Study & Subjects

Genetic factors in colorectal cancer Oral Health Pathology and Treatment DNA Repair Mechanisms

Publication details

Journal / source
Cureus
Volume
18
Issue
1
Pages
e100640–e100640
Publication date
2 January 2026
Language
EN