Successful Treatment of Extragenital Lichen Sclerosus With Roflumilast 0.3% Cream: A Report of Two Cases
Abstract
Extragenital lichen sclerosus (EGLS) is often resistant to first-line ultrapotent corticosteroids, with few steroid-sparing options available. Topical roflumilast has been approved by the US Food and Drug Administration (FDA) for an expanding number of indications in dermatology, including plaque psoriasis, atopic dermatitis, and, most recently, seborrheic dermatitis. We present two cases of symptomatic EGLS, who both demonstrated clinical improvement using roflumilast 0.3% cream as early as one month of follow-up.
Fields of Study & Subjects
Genital Health and Disease
Dermatology and Skin Diseases
Urological Disorders and Treatments
Publication details
- Journal / source
- Cureus
- Volume
- 18
- Issue
- 1
- Pages
- e100823–e100823
- Publication date
- 5 January 2026
- Language
- EN