Skin Fragility-Woolly Hair Syndrome (SFWHS): A Case Report

Cureus 2026 Open access

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Authors: Ahmed A. Almousa, Saud Binsufayan, Mohammad Almazied, Tasneem Hani Aldraye, Saud Alsharif
DOI: 10.7759/cureus.100931
Cited by: 0
References: 4

Abstract

Skin fragility, palmoplantar keratoderma, and characteristic woolly hair are defining features of skin fragility-woolly hair syndrome (SFWHS), an extremely rare inherited disorder. This condition is classified within the group of desmosomal disorders, which are associated with compromised structural integrity of the skin and hair. Clinically, affected individuals often present with hair fragility, fragile skin, recurrent erosions, nail abnormalities, and varying degrees of palmoplantar thickening beginning in early childhood. In this case report, we describe a patient with this extremely rare syndrome.

Fields of Study & Subjects

Hair Growth and Disorders Skin and Cellular Biology Research Cancer and Skin Lesions

Publication details

Journal / source
Cureus
Volume
18
Issue
1
Pages
e100931–e100931
Publication date
6 January 2026
Language
EN