Iodine-Based Wound Dressing Versus Antibiotic Therapy for Postoperative Symptom Relief in Third Molar Surgery

OBJECTIVES: This prospective, non-randomized comparative clinical study aimed to explore postoperative symptom outcomes associated with iodine-based wound dressings following third molar extraction, compared with conventional primary wound closure and postoperative antibiotic therapy. MATERIALS AND METHODS: This prospective, non-randomized comparative clinical study was conducted at the Department of Oral and Maxillofacial Surgery, Tartu University Hospital, between May 1, 2022, and December 31, 2023.A total of 68 patients undergoing third molar extraction were assigned to four groups based on postoperative management. Group A received antibiotic therapy, Group B received iodoform gauze, Group C underwent extraction of both upper and lower third molars with iodoform gauze applied to the lower site, and Group D served as a control group without preventive measures. Postoperative pain, swelling, chewing difficulty, and drowsiness were assessed using questionnaires and visual analog scales where applicable. RESULTS: Patients treated with iodoform gauze (Groups B and C) demonstrated postoperative outcomes comparable to those observed in the antibiotic group (Group A), with a non-significant trend toward shorter pain duration. Group C reported the most favorable subjective recovery outcomes. The control group experienced the longest duration of postoperative pain and chewing difficulties. CONCLUSION: Local iodine-based wound management following third molar extraction is a comparable option to systemic antibiotic therapy.