Oxidant and Antioxidant Levels in Different Stages of Chronic Kidney Disease
Abstract
Background Chronic kidney disease (CKD) is a progressive renal disorder strongly associated with oxidative stress, which contributes to renal damage and systemic complications. Oxidative stress results from an imbalance between the production of reactive oxygen species (ROS) and antioxidant defence mechanisms. This study aimed to evaluate oxidant and antioxidant levels across different stages of CKD. Methods This cross-sectional comparative study was conducted on 180 subjects, including 90 CKD patients and 90 healthy controls. CKD patients were classified into Stage III, Stage IV, and Stage V. Serum malondialdehyde (MDA) and superoxide dismutase (SOD) were measured to assess oxidative stress using standard laboratory assays. Data were analysed using one-way ANOVA with Brown-Forsythe adjustment, and a p-value
Fields of Study & Subjects
Dialysis and Renal Disease Management
Chronic Kidney Disease and Diabetes
Acute Kidney Injury Research
Publication details
- Journal / source
- Cureus
- Publisher
- Springer Science and Business Media LLC
- Volume
- 18
- Issue
- 1
- Pages
- e102115–e102115
- Publication date
- 22 January 2026
- Language
- EN