Linitis Plastica in a Patient With a BRCA2 Mutation: A Case Report
Abstract
BRCA2 pathogenic mutations are well-established risk factors for breast, ovarian, prostate, and pancreatic cancers. However, the relationship between BRCA2 mutations and gastric cancer (GC) remains understudied. This case involves a patient with a pathogenic BRCA2 mutation diagnosed with linitis plastica, a diffuse form of GC characterized by stiffening of the gastric lining, akin to a “leather bottle.” This case highlights the importance of further research to elucidate the connection between GC and BRCA2 mutations, which may lead to expanded surveillance guidelines for affected individuals. Clinicians should consider the potential elevated risk of GC in patients with BRCA2 mutations.
Fields of Study & Subjects
Gastric Cancer Management and Outcomes
BRCA gene mutations in cancer
Genetic factors in colorectal cancer
Publication details
- Journal / source
- Cureus
- Volume
- 18
- Issue
- 1
- Pages
- e102423–e102423
- Publication date
- 27 January 2026
- Language
- EN