A Retrospective Review of Swallowing Outcomes for Oropharyngeal and Laryngeal Cancer Patients After Chemoradiation: A Single Institution Report

PURPOSE: To collect our institutional experience and assess dysphagia prior to, during, and after chemoradiation for oropharyngeal and laryngeal cancer patients. This data can be used for future comparison with patients treated with newer radiation therapy techniques that are designed to decrease cumulative dose to swallowing structures. Methods: A retrospective review of oropharyngeal and laryngeal cancer patients treated with chemoradiation with curative intent at the University of Iowa Healthcare (UIHC) from 2019-2022. Manual chart review identified baseline patient data, tumor characterization, and the following dysphagia measures: EAT-10, Penetration and Aspiration Scale (PAS), and oropharyngeal motility study (OPMS). Linear mixed effects regression was used to estimate the rate of change in mean scores from baseline, and to assess differences in baseline scores and the rate of change across disease and clinical characteristics. Results: Of the 109 patients, 89 patients were treated for oropharyngeal cancer and 20 were treated for laryngeal cancer. There was a statistically significant increase in the mean EAT-10 scores from baseline to initial follow-up (10.14 vs. 13.27, p=0.03) for all patients. The rate of change in EAT-10 scores also significantly differed (p