Bayesian Re-analysis of Two-Year Outcomes in the Platelet-Rich Plasma in Achilles Tendon Healing 2 (PATH-2) Trial: Platelet-Rich Plasma for Achilles Tendon Rupture
Abstract
The platelet-rich plasma in achilles tendon healing 2 (PATH-2) trial is the largest randomized study of platelet-rich plasma (PRP) in acute Achilles tendon rupture. While the original frequentist analysis showed no significant benefit, such methods cannot quantify the probability of clinically meaningful improvement. We conducted a Bayesian re-analysis of PATH-2 data (n = 177) with Achilles tendon total rupture score (ATRS) and patient-specific functional scale (PSFS) at 24 months as outcomes. Minimally clinically important differences (MCIDs) were defined as 8 ATRS points and 2.3 PSFS points. Across flat, neutral, optimistic, and pessimistic priors, posterior probabilities of PRP providing benefit ≥MCID were
Fields of Study & Subjects
Tendon Structure and Treatment
Periodontal Regeneration and Treatments
Foot and Ankle Surgery
Publication details
- Journal / source
- Cureus
- Volume
- 18
- Issue
- 1
- Pages
- e102519–e102519
- Publication date
- 28 January 2026
- Language
- EN