Association of Oxidative Stress With Biochemical Markers in Diabetic and Non-diabetic Chronic Kidney Disease Patients: A Cross-Sectional Study

Background Chronic kidney disease (CKD) is exacerbated by oxidative stress (OS), which accelerates renal injury and cardiovascular complications. Diabetes intensifies OS via hyperglycemia and mitochondrial dysfunction, promoting faster decline in diabetic kidney disease (DKD). This study compares OS markers with standard biochemical parameters in diabetic versus non-diabetic CKD to inform risk stratification and management. Methods This hospital-based, cross-sectional study enrolled 240 CKD patients (108 diabetic, 132 non-diabetic) over one year. Demographics, clinical data, and biochemical parameters-including fasting/postprandial blood sugar (FBS/PPBS), HbA1c, creatinine, urea, uric acid, estimated glomerular filtration rate (eGFR), and malondialdehyde (MDA)-were collected. Group comparisons, ANOVA, post-hoc Tukey, and Pearson's correlation assessed associations, with p