Transnasal–Transoral Endoscopic Surgery Followed by Radiotherapy for Nasopharyngeal Spindle Cell Carcinoma
Abstract
Spindle cell carcinoma (SpCC) is a rare and aggressive variant of squamous cell carcinoma characterized by the coexistence of epithelial and mesenchymal components, accounting for 3 years after surgery, with stable perioperative renal function. This case highlights the advantages of the transnasal-transoral endoscopic approach in providing adequate visualization and access to the nasopharynx while reducing surgical morbidity. The combination of maximal cytoreductive endoscopic surgery and postoperative radiotherapy may represent an effective and less invasive treatment option for nasopharyngeal SpCC, particularly in patients with significant comorbidities.
Fields of Study & Subjects
Head and Neck Surgical Oncology
Head and Neck Cancer Studies
Esophageal Cancer Research and Treatment
Publication details
- Journal / source
- Cureus
- Volume
- 18
- Issue
- 2
- Pages
- e103001–e103001
- Publication date
- 4 February 2026
- Language
- EN