Successful Treatment of Histiocytic Sarcoma in Childhood

Cureus 2026 Open access

Read full text
Authors: Haroula Tsipou, Georgia Avgerinou, Stavros Glentis, Kalliopi S. Stefanaki, Antonis Kattamis
DOI: 10.7759/cureus.103409
Cited by: 0
References: 19

Abstract

Histiocytic sarcoma (HS) is a rare malignant neoplasm that belongs to malignant histiocytoses. HS primarily occurs in adult males and is exceptionally uncommon in pediatric populations. Extranodal regions represent the most common sites of HS manifestation. Diagnosis necessitates histopathological evidence of neoplasm, along with verification of cellular origin through specialized studies. Here, we describe a case of a three-year-old female toddler with HS in her calf that was successfully treated with the chemotherapy protocol of Langerhans Cell Histiocytosis (LCH)-IV, the International Collaborative Treatment Protocol for Children and Adolescents with LCH, version 1.3.

Fields of Study & Subjects

Histiocytic Disorders and Treatments Sarcoma Diagnosis and Treatment Autoimmune and Inflammatory Disorders Research

Publication details

Journal / source
Cureus
Volume
18
Issue
2
Pages
e103409–e103409
Publication date
11 February 2026
Language
EN