Nitrous Oxide and Oral Sedation for Managing Dental Anxiety in Children: A Systematic Review

Dental anxiety is common among children and frequently leads to avoidance of dental treatment, premature tooth loss, and broader health concerns such as bite misalignment. This systematic review examines nitrous oxide-oxygen (N₂O/O₂) and oral sedation (e.g., midazolam, hydroxyzine) as minimally invasive options for children aged 2-12 years, using the Patient/Population, Intervention, Comparison, and Outcome (PICO) framework to guide analysis. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020, we searched PubMed, Cochrane, and Scopus (2015-2025), including 25 studies (n≈12,500 participants) with randomized controlled trials (RCTs), cohorts, and reviews. Risk of bias was assessed via Risk Of Bias In Non-randomized Studies-of Interventions (ROBINS-I) and A MeaSurement Tool to Assess systematic Reviews 2 (AMSTAR-2); qualitative synthesis was chosen due to heterogeneity. N₂O excelled in mild anxiety (85-92% efficacy,