Assessing Mortality Prediction: Comparing the Effectiveness of the Fournier Gangrene Severity Index and the Uludag Index

Background Fournier's gangrene (FG) is a fulminant necrotizing infection associated with substantial morbidity and high mortality. Early and accurate risk stratification is essential to guide clinical decision-making. The Fournier Gangrene Severity Index (FGSI) and the Uludag Fournier Gangrene Severity Index (UFGSI) are widely used prognostic tools; however, their comparative performance in Mexican populations remains insufficiently characterized. This study aimed to assess the association of FGSI and UFGSI with in-hospital mortality and to explore their comparative prognostic performance in a Mexican cohort. Methodology This retrospective cohort study was conducted at a tertiary-level public hospital in Mexico City. We included 65 adults with confirmed FG treated between July 2022 and February 2025. Clinical, demographic, and laboratory data were collected to calculate FGSI, UFGSI, and the Age-Adjusted Charlson Comorbidity Index. Survivors and non-survivors were compared using Student's t-test and chi-square tests, and associations with in-hospital mortality were evaluated using multivariate logistic regression with traditional and adjusted cutoff values. Statistical significance was defined as a p-value