Efficacy and Safety of Vaginal Estradiol Hemihydrate as an Adjunct to Oral Estradiol Valerate in Hormone Replacement Therapy-Frozen Embryo Transfer (HRT-FET) Cycles: A Retrospective Study
Abstract
OBJECTIVE: To evaluate the efficacy and safety of vaginal estradiol hemihydrate as an adjunct to oral estradiol valerate in improving endometrial thickness and pregnancy outcomes in the hormone replacement therapy-frozen embryo transfer (HRT-FET) cycle. MATERIALS AND METHODS: This retrospective observational study was conducted at Kamala Polyclinic and Nursing Home, Mumbai, India, and included women aged 25-42 years undergoing HRT-FET treatment cycles between May and July 2024. Only those patients were included in this study whose endometrial thickness was
Fields of Study & Subjects
Reproductive System and Pregnancy
Reproductive Biology and Fertility
Reproductive Health and Technologies
Publication details
- Journal / source
- Cureus
- Volume
- 18
- Issue
- 2
- Pages
- e104347–e104347
- Publication date
- 26 February 2026
- Language
- EN