Exponential Modeling and Confidence Interval Analysis Reveal Limited Precision of History, Electrocardiogram, Age, Risk Factors, and Troponin (HEART) Score Risk Stratification

Cureus 2026 Open access

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Authors: David Dobies
DOI: 10.7759/cureus.104506
Cited by: 0
References: 7

Abstract

Using exponential modeling and confidence interval (CI) analysis, this report evaluates the internal risk behavior of the history, electrocardiogram, age, risk factors, and troponin (HEART) score. The exponential model major adverse cardiac event (MACE %) = 0.79 × e(0.44·HEART) (R²≈0.99) demonstrates substantial CI overlap across HEART 1-3. Only HEART 0-1, combined with non-ischemic ECG and serial negative high-sensitivity troponins, reliably satisfies the American College of Cardiology/American Heart Association (ACC/AHA)

Fields of Study & Subjects

Acute Myocardial Infarction Research Cardiac Imaging and Diagnostics Coronary Interventions and Diagnostics

Publication details

Journal / source
Cureus
Volume
18
Issue
3
Pages
e104506–e104506
Publication date
1 March 2026
Language
EN