A Prospective Observational Study on Serum Lactate Dehydrogenase and Uric Acid Levels in Hypertensive Disorders of Pregnancy and Prediction of Fetomaternal Outcome

Introduction Hypertensive disorders of pregnancy are a major cause of maternal and perinatal morbidity and mortality, particularly in low- and middle-income countries. Early identification of women at risk using simple biochemical markers may aid in timely intervention and improved outcomes. Serum lactate dehydrogenase (LDH) and uric acid have been proposed as indicators of disease severity in hypertensive pregnancies. The study aimed to evaluate the association of serum LDH and uric acid levels with the severity of hypertensive disorders of pregnancy and their relationship with maternal and fetal outcomes in women with hypertensive disorders of pregnancy. Materials and methods This prospective observational study was conducted in a tertiary care teaching hospital from March 2024 to December 2025. A total of 165 pregnant women with hypertensive disorders of pregnancy and gestational age ≥20 weeks were enrolled. Serum LDH and uric acid levels were measured antenatally and after delivery using standard laboratory methods. Normal values were defined as LDH