Blue Rubber Bleb Nevus Syndrome: Case-Driven Insights Into a Rare Cause of Refractory Gastrointestinal Bleeding

Cureus 2026 Open access

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Authors: Edwin Ornelas Escobedo, Laura Escobedo, Santiago Philibert‐Rosas, Ceriolith Tenorio-Flores, Ariosto H. Hernández-Lara, Luis Eduardo Zamora Nava
DOI: 10.7759/cureus.104842
Cited by: 0
References: 18

Abstract

Blue rubber bleb nevus syndrome (BRBNS) is a rare vascular disorder causing chronic iron-deficiency anemia from gastrointestinal (GI) bleeding. We described the case of a 17-year-old Latin American patient with refractory anemia, cutaneous papules, and blue nevi. Endoscopic evaluations identified multiple bleeding lesions through the GI tract. Hot snare resection and clip placement achieved significant clinical improvement and stabilized hemoglobin levels. This case underscores the critical role of video capsule endoscopy and highlights the need for heightened awareness and diagnostic expertise in managing BRBNS.

Fields of Study & Subjects

Gastrointestinal Bleeding Diagnosis and Treatment Vascular Malformations and Hemangiomas Vascular Anomalies and Treatments

Publication details

Journal / source
Cureus
Volume
18
Issue
3
Pages
e104842–e104842
Publication date
7 March 2026
Language
EN