Successful Outcome of Acute Promyelocytic Leukemia Complicated by Bone Marrow Necrosis and Posterior Reversible Encephalopathy Syndrome, During Treatment With an All-Trans Retinoic Acid Plus Arsenic Trioxide-Based Regimen

Cureus 2026 Open access

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Authors: Theodora Maria Venou, Maria Mainou, Konstantina Voura, Ester S Mbonde Mouangue, Nicolaos A. Flaris, Efthymia Vlachaki
DOI: 10.7759/cureus.104972
Cited by: 0
References: 18

Abstract

fusion gene and frequent coagulopathy. All-trans retinoic acid (ATRA) plus arsenic trioxide (ATO)-based regimens achieve excellent complete remission rates exceeding 95% with durable molecular responses. However, treatment-related and disease-related complications may occur during therapy. We report a case of a 57-year-old man with APL complicated by bone marrow necrosis, pulmonary complications, and posterior reversible encephalopathy syndrome. Multidisciplinary supportive care with continuation of ATRA-ATO therapy resulted in complete hematologic and molecular remission. This case highlights the importance of recognizing and managing complex complications in APL while maintaining curative therapy.

Fields of Study & Subjects

Retinoids in leukemia and cellular processes Acute Myeloid Leukemia Research Hematological disorders and diagnostics

Publication details

Journal / source
Cureus
Volume
18
Issue
3
Pages
e104972–e104972
Publication date
10 March 2026
Language
EN