Unveiling a Rare and Aggressive Bladder Tumor: A Case Report of Plasmacytoid Urothelial Carcinoma

Cureus 2026 Open access

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Authors: Fatima Zahra Bouayed, Mohammed Amine Guerrouaz, Hanane Sebbar, Ahmed BenSghier, Soufiane Berhili, Mohamed Moukhlissi, Loubna Mezouar
DOI: 10.7759/cureus.105275
Cited by: 0
References: 11

Abstract

In 1991, Sahin et al. reported the first documented case of plasmacytoid urothelial carcinoma (PUC). A rare and highly aggressive subtype that was recently incorporated into the WHO classification of urothelial carcinomas, representing 1-3% of cases of bladder cancers. The tumor cells are characterized by eccentrically placed nuclei with abundant eosinophilic cytoplasm and demonstrate positive immunostaining for CD138, and this variant is generally linked to an unfavorable prognosis. In this article, we present the case of a 61-year-old male diagnosed with PUC managed with concurrent chemoradiotherapy.

Fields of Study & Subjects

Bladder and Urothelial Cancer Treatments Urinary and Genital Oncology Studies Urinary Bladder and Prostate Research

Publication details

Journal / source
Cureus
Volume
18
Issue
3
Pages
e105275–e105275
Publication date
15 March 2026
Language
EN