Refractory Gastric Antral Vascular Ectasia as a Sentinel for "Burned-Out" Metabolic Dysfunction-Associated Steatotic Liver Disease and Rapid Hepatocellular Carcinoma Progression in a Post-transcatheter Aortic Valve Implantation Dialysis Patient

Read full text
Authors: Willy Stéphane Kengne, Baro Deressa, Luc Lasser
Cited by: 0
References: 13

Abstract

Gastric antral vascular ectasia (GAVE) is challenging to manage in multimorbid patients, where etiology varies between cirrhosis, autoimmune disease, or chronic kidney disease (CKD). We report a 76-year-old man with transcatheter aortic valve implantation (TAVI), hemodialysis, and past alcohol abuse presenting with refractory GAVE. Baseline imaging in 2021 showed metabolic dysfunction-associated steatotic liver disease (MetALD) with advanced fibrosis and severe steatosis (S3). Two years later (April 2023), during acute bleeding, despite six sessions of endoscopic ablation, hemostasis was elusive. At this stage, elastography showed deceptive radiological evidence of complete steatosis regression (S0) with stable fibrosis. This "pseudo-normalization", likely driven by fibrosis replacing fat and tumor-induced lipid mobilization, masked the underlying pathology. Eight months post-bleeding (December 2023), clinical deterioration revealed decompensated cirrhosis and a massive 6.7 cm hepatocellular carcinoma (HCC). Diagnostic obscurity caused by steatosis resolution in "burned-out" MetALD can be fatal. In this patient, the refractory nature of the GAVE, rather than its mere presence, served as a crucial sentinel sign for occult malignancy and advancing portal hypertension. The patient was referred for palliative care and remains under supportive management.

Fields of Study & Subjects

Liver Disease and Transplantation Liver Disease Diagnosis and Treatment Gastrointestinal Bleeding Diagnosis and Treatment

Publication details

Journal / source
Cureus
Volume
18
Issue
3
Pages
e105316–e105316
Publication date
16 March 2026
Language
EN