Direct Oral Anticoagulants Versus Warfarin in Atrial Fibrillation With Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Cureus 2026 Open access

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Authors: Ali S Metwaly, Aymen A Alqurain, Faisal Alghanim, Nada Alghamdi, Ragad Alsudairi, Aref Y Dayl, Basil S Alghamdi, Osaid H Niazi, Fadel M Alfaraj, Nasser Q Alsharif, Amal Y Alfaifi, Mohammed A Alzahrani
+2 more Tala H Abdulmgid, Zainab Alkaf
DOI: 10.7759/cureus.106043
Cited by: 1
References: 52

Abstract

Patients with non-valvular atrial fibrillation (AF) and advanced chronic kidney disease (CKD), including those with end-stage kidney disease (ESKD) on dialysis, present a unique therapeutic challenge. This population is at an elevated risk for both thromboembolic events and severe bleeding complications. Because patients with creatinine clearance

Fields of Study & Subjects

Atrial Fibrillation Management and Outcomes Venous Thromboembolism Diagnosis and Management Acute Kidney Injury Research

Publication details

Journal / source
Cureus
Publisher
Springer Science and Business Media LLC
Volume
18
Issue
3
Pages
e106043–e106043
Publication date
28 March 2026
Language
EN