Topical Steroid-Induced Cushing Syndrome in an 18-Month-Old Child: A Case Report
Abstract
Topical corticosteroids are widely used in pediatric dermatology and are generally considered safe when used appropriately; however, prolonged or inappropriate use, particularly of high-potency agents, may lead to significant systemic adverse effects. This case report describes an 18-month-old female who presented with rapid weight gain and cushingoid features following prolonged application of clobetasol propionate for diaper dermatitis. Clinical evaluation revealed generalized obesity, moon facies, facial plethora, and dorsal hypertrichosis, while laboratory investigations demonstrated markedly suppressed afternoon serum cortisol levels (~2 µg/dL; pediatric reference range: 3-13 µg/dL) and plasma adrenocorticotropic hormone (ACTH) levels
Fields of Study & Subjects
Adrenal Hormones and Disorders
Pituitary Gland Disorders and Treatments
Dermatology and Skin Diseases
Publication details
- Journal / source
- Cureus
- Publisher
- Springer Science and Business Media LLC
- Volume
- 18
- Issue
- 5
- Pages
- e109303–e109303
- Publication date
- 20 May 2026
- Language
- EN