Intraperitoneal Ropivacaine versus Levobupivacaine for Postoperative Analgesia in Laparoscopic Surgeries: A Randomised Controlled Trial

Introduction: Management of postoperative pain in laparoscopic surgeries remains challenging, often necessitating multimodal analgesic strategies to enhance patient comfort and recovery. Intraperitoneal Local Anaesthetic (IPLA) administration offers a promising approach for pain control while minimising systemic opioid use and associated side-effects. Ropivacaine and levobupivacaine are commonly used long-acting amide local anaesthetics with favourable safety profiles. Aim: The present aimed to compare the efficacy of intraperitoneal ropivacaine versus levobupivacaine for postoperative analgesia in patients undergoing elective laparoscopic surgeries. Materials and Methods: In the present double blinded, randomised controlled study, 48 patients {American Society of Anaesthesiologists (ASA) I-II, aged 18-65 years} undergoing elective laparoscopic surgeries were randomly allocated into two groups. Group R (n=24) received 20 mL 0.25% ropivacaine and group L (n=24) received 20 mL 0.25% levobupivacaine intraperitoneally before trocar removal. Postoperative pain was assessed using Visual Analog Scale (VAS) scores over 12 hours. Haemodynamic parameters, rescue analgesic requirements, and side-effects were monitored. Data were analysed using Statistical Package for Social Sciences (SPSS) version 26, with independent t-tests for normally distributed numerical variables and Chi-square tests for categorical variables, with statistical significance set at p