Coagulation Profile in Type 2 Diabetes Mellitus and its Association with Glycaemic Control and Long-term Complications: A Cross-sectional Study

Introduction: Diabetes Mellitus (DM) causes numerous complications due to the formation of Advanced Glycation Endproducts (AGEs) in the presence of persistent hyperglycaemia. These products also alter the coagulation activity, leading to microvascular and macrovascular complications in the longterm. Diabetic patients are not routinely screened for assessing their thrombotic status Prothrombin Time (PT) and activated Partial Thromboplastin Time (aPTT) that could be associated with their glycaemic index (HbA1C). Aim: To evaluate the coagulation profile among Type 2 Diabetes Mellitus (T2DM) patients and its association with their glycaemic index and long-term complications. Materials and Methods: This cross-sectional observational study was conducted in the Department of Pathology, IQ City Medical College and Hospital (tertiary care hospital), Durgapur,West Bengal, India over a period of six months April 2023 to October 2023, in which 60 diabetic (patients with pre-diagnosed type II diabetes mellitus) and 60 non diabetic (apparently healthy individuals) were included. Glycosylated Haemoglobin (HbA1c), PT, aPTT were compared between diabetic and non diabetic, the diabetic with good glycaemic control (HbA1C 7) and diabetic with and without complications by Student’s t-test using Statistical Package for Social Sciences (SPSS) version 16.0. The p-value