The Total Synthesis of Chlorotricolide: the Top Half
Abstract
The total synthesis of the top half of chlorotricolide 2, is described. The top half 65 was prepared in 14 steps (10% overall yield) from tartaric acid. The potential usefulness of this top half in the total synthesis of chlorotricolide was demonstrated by connection to bottom half models. Successful deprotection of the α-hydroxy-tetronic acid dimethyl ether moiety is also described. See figures in PDF of thesis.
Fields of Study & Subjects
Organic Chemistry Synthesis Methods
Advanced Synthetic Organic Chemistry
Biological Activity of Diterpenoids and Biflavonoids
Publication details
- Journal / source
- Caltech Library
- Publication date
- 12 February 2026
- Language
- EN
- Document type
- Thesis