Hepatorenal indices of toxicity in rats treated with aqueous Khaya senegalensis stem bark extract

ENGLISH Background: Therapeutic use of plant materials is not without toxic impacts on metabolic and excretory processes in the body. Objective: This study investigated toxicological impacts of Khaya senegalensis stem bark using plasma levels of hepatic and renal dysfunction biomarkers. Methods: Forty (40) Wistar rats divided into five equal groups (n=8) was administered with distil water (control) and graded doses of aqueous Khaya senegalensis stem bark extract (test) for eight weeks. Blood was collected to determine aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total protein, albumin, urea, creatinine and bilirubin (total and conjugated) levels. Liver and kidneys were harvested for histological studies. Results: A significant increase (p