Fe3O4/KF/Clinoptilolite@MWCNTs promoted green synthesis of benzofuro naphthyridines

In this research we synthesized new derivatives of benzofuro naphthyridines in high yields using multicomponent reaction of the 2-amino-4-hydroxyacetophenone, isopropenylacetylene, aldehyde derivatives in the presence of catalytic amounts of Fe3O4/KF/Clinoptilolite@MWCNTs magnetic nanocomposites using ionic liquid as green solvent at room temperature. Also, employing Gram-positive and Gram-negative bacteria in the disk diffusion procedure confirmed the some furo[2,3-f]quinoline derivatives antimicrobial effect. The results showed that synthesized compounds prevented the bacterial growth. This used procedure for preparation of furo[2,3-f]quinoline derivatives has some advantages such as low reaction time, product with high yields, simple separation of catalyst and products.