Synthesis oxazinoazepine derivatives using multicomponent reaction of isatins

In this study, we synthesized oxazinoazepine derivatives in high yields using multicomponent reactions of isatins, alkyl bromides, activated acetylenic compounds and ethyl glycinate in the presence of Fe3O4/CuO@MWCNT as a high performance catalyst in water at room temperature. Also, the catalytic activity of the green synthesized Fe3O4/CuO@MWCNT MNCs was evaluated in the reduction of organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions. The results indicated that the biosynthesized NCs have very high and effective catalytic activity for organic pollutants within few seconds. Also, the antimicrobial activity of some synthesized compounds proved by employing the disk diffusion test on Gram-positive and Gram-negative bacteria. This procedure has some benefits such as short reaction time, product with excellent yields, simple catalyst and products separation.