Data for Heparin stabilised iron oxide for MR applications: a relaxometric study

Superparamagnetic nanoparticles have strong potential in biomedicine and have seen application as clinical magnetic resonance imaging (MRI) contrast agents, though their popularity has plummeted in recent years, due to low efficacy and safety concerns, including haemagglutination. Using an in situ procedure, we have prepared colloids of magnetite nanoparticles, exploiting the clinically approved anti-coagulant, heparin, as a templating stabiliser. These colloids, stable over several days, produce exceptionally strong MRI contrast capabilities particularly at low fields, as demonstrated by relaxometric investigations using nuclear magnetic resonance dispersion (NMRD) techniques and single field r1 and r2 relaxation measurements. This behaviour is due to interparticle interactions, enhanced by the templating effect of heparin, resulting in strong magnetic anisotropic behaviour which closely maps particle size. The nanocomposites have also reliably prevented protein-adsorption triggered thrombosis typical of non-stabilised nanoparticles, showing great potential for in vivo MRI diagnostics. All clotting data, All NMRD data, All raw data single field relaxivity, Average clotting times, DLS_long term, FTIR, Magnetisation, Raman, Sample 1_TEM avg, Sample 2_TEM avg, Sample 3_TEM avg, Sample 3_TEM avg, Sample 4_TEM avg, Sample 5_TEM avg, Single field relaxivity, Unmodified Fe3O4_TEM avg, XRD_all data