Data for Biotinylated photoactive Pt(IV) anticancer complexes

Warwick Research Archive Portal (University of Warwick) 2026 Dataset Open access

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Authors: Huayun Shi, Cinzia Imberti, Huaiyi Huang, Ian Hands-Portman, Peter John Sadler
DOI: 10.82444/warw.33805963.v1
Cited by: 0

Abstract

Novel biotinylated diazido-Pt(IV) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-trans-[Pt(py)2(N3)2(biotin)(OH)] (2a) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with 2a. Data record consists of a rar archive, containing the data, and an accompanying readme file. The 1H NMR and 13C NMR spectra and HR-MS spectra of complexes 2a and 2b are listed in the dataset. More information is listed in the ESI and the accompanying readme file.

Fields of Study & Subjects

Metal complexes synthesis and properties Molecular Junctions and Nanostructures Biotin and Related Studies

Publication details

Journal / source
Warwick Research Archive Portal (University of Warwick)
Publication date
15 September 2026
Language
EN
Document type
Dataset