Management of Corneal Opacity Associated with Bovine Trypanosomosis Using Placental Extract: A Case Report

A six years old female cross bred Jersey cow was presented to the Veterinary Clinical Complex, BVC, BASU, Patna, Bihar with the history of inappetance, bilateral ocular changes and lacrimation, apparent blindness and drop in milk production. Clinical examination revealed body temperature of 103.2 0 F, pale conjunctival mucus membranes, bilateral corneal opacity with hyphema and lacrimation, stamping of feet and salivation. Based on the clinical history, the animal was suspected for haemoprotzoal infection. The blood was collected for blood smear examination and haemato-biochemical estimations. Microscopic examination (oil immersion objective) of Giemsa stained blood smear revealed characteristic haemoflagellates, the Trypanosoma spp. Hematological examination revealed anemia, and serum bilirubin was elevated. Based on clinical and blood smear examination, the case was diagnosed for corneal opacity associated with trypanosomosis. Treatment was started with Inj. Quinopyramine sulphate and chloride @ 5 mg /kg, SC (single dose) after infusion of 2.0 litre of Dextrose saline solution. Day after initial therapy, Inj Placentrex (Human placental extract) 1ml was administered sub-conjunctively as a single dose in both eyes. Further, eye drop Prednisolone acetate two drops TID was prescribed for two week as follow-up treatment. Clinical recovery with complete resolution of corneal opacity was observed after 3 week treatment, and the post therapeutic blood sample was also found negative for any haemoparasites. A six years old female cross bred Jersey cow was presented to the Veterinary Clinical Complex, BVC, BASU, Patna, Bihar with the history of inappetance, bilateral ocular changes and lacrimation, apparent blindness and drop in milk production. Clinical examination revealed body temperature of 103.2 0 F, pale conjunctival mucus membranes, bilateral corneal opacity with hyphema and lacrimation, stamping of feet and salivation. Based on the clinical history, the animal was suspected for haemoprotzoal infection. The blood was collected for blood smear examination and haemato-biochemical estimations. Microscopic examination (oil immersion objective) of Giemsa stained blood smear revealed characteristic haemoflagellates, the Trypanosoma spp. Hematological examination revealed anemia, and serum bilirubin was elevated. Based on clinical and blood smear examination, the case was diagnosed for corneal opacity associated with trypanosomosis. Treatment was started with Inj. Quinopyramine sulphate and chloride @ 5 mg /kg, SC (single dose) after infusion of 2.0 litre of Dextrose saline solution. Day after initial therapy, Inj Placentrex (Human placental extract) 1ml was administered sub-conjunctively as a single dose in both eyes. Further, eye drop Prednisolone acetate two drops TID was prescribed for two week as follow-up treatment. Clinical recovery with complete resolution of corneal opacity was observed after 3 week treatment, and the post therapeutic blood sample was also found negative for any haemoparasites.