Serum P Selectin Levels amongst Hypertensive Patients in North- Central Nigeria: A Comparative Study

Background: Hypertension is a common and important major global health problem affecting more than 927 million people worldwide. Elevated levels of P selectin correlates with platelet activation. Platelet activation plays a key role in the complications of hypertension. Aim: To determine the serum levels of P selectin in hypertensive patients and to compare the serum P selectin in control subjects in North central Nigeria. Methods: This is a cross-sectional comparative study conducted among 151 Hypertensives and 150 Normotensive controls in Federal Medical Centre Keffi Nasarawa State (North Central Nigeria). Soluble P-selectin levels were assessed using the enzyme-linked immunosorbent assay technique. Five millilitres (5mls) of venous blood were aseptically collected by venepuncture from each participant into plain tube and analysed using Elabsceince ELISA kits. Sample sized was determined using the Using the Leslie and Kish formula for sample size determination and a simple random sampling method was used to recruit participants. Differences between groups was assessed by the Mann Whitney U and Wilcoxon signed ranked test for nonparametric variables as appropriate. Pearson’s correlation coefficients were calculated to evaluate the association between relevant parameters. Data obtained were analysed using SPSS version 27, and results considered to be significant at p