Substituted Arylidene Imidazolones: Synthesis, Spectral Characterization and Molecular Docking Studies
Abstract
Ten analogues of acetylphenyl tethered imidazolones (4.12a-j) from 4-arylidene-2-phenyloxazol-5(4H)-ones were prepared and characterised by IR, 1HNMR, 13CNMR and mass spectra. All the analogues have shown moderate to good antibacterial activity against E. coli, P. aeruginosa, B. subtilis, and S. aureus. By means of FabI of S. aureus, docking studies were carried out. Altogether, the compounds were proven to be inhibitors of enoylacylcarrier proteinreductase.
Fields of Study & Subjects
Synthesis and Reactions of Organic Compounds
Heterocyclic Compound Synthesis and Bioactivity
Synthesis and Biological Evaluation
Publication details
- Journal / source
- Book Publisher International (a part of SCIENCEDOMAIN International)
- Pages
- 103–113
- Publication date
- 30 January 2026
- Language
- EN
- Document type
- Book chapter