Comparative Clinical Efficacy of Cefovecin and Marbofloxacin in the Treatment of Canine Pyoderma

Pyoderma is defined as a pyogenic bacterial infection of the skin. In the present study, the comparative therapeutic efficacy of cefovecin and marbofloxacin was evaluated in dogs clinically affected with pyoderma. This study was conducted to compare the clinical and therapeutic efficacy of marbofloxacin and cefovecin in the treatment of canine pyoderma. Canine pyoderma cases were identified from dogs presenting with various skin disorders at the Veterinary Clinical Complex, Jabalpur (MP), between July and December 2025. Of the 444 dogs examined for dermatological conditions, 75 (16.89%) were diagnosed with pyoderma. Therapeutic evaluation was carried out based on clinical response scoring, which included assessment of pruritus score, lesion score (presence and distribution of lesions) and coat condition score. The overall therapeutic response was determined by comparing pre-treatment (day 0) and post treatment (28 day) scores. A comparative trial conducted on 12 dogs demonstrated that both treatment regimens resulted in significant improvement in pruritus, resolution of skin lesions and enhancement of coat condition. However, the cefovecin treated group showed significantly higher clinical efficacy compared to the marbofloxacin treated group, as evidenced by greater reduction in clinical response scoring.