Psychosis Related to Nitrous Oxide Misuse: A Case Series and Systematic Review

Clinical Psychopharmacology and Neuroscience 2026 Open access

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Authors: Laura Garriga-Solé, Germán Ortega-Hernández, X. Acosta-Villalobos, Lara Grau-López, Josep Antoni Ramos-Quiroga, Raúl Felipe Palma-Álvarez
DOI: 10.9758/cpn.25.1394
Cited by: 2
References: 38

Abstract

O may be associated with psychotic episodes, particularly among young, heavy users with underlying vulnerabilities. Psychiatric and neurological symptoms are frequently observed. Although outcomes vary, treatment involving abstinence, vitamin B12 supplementation, and antipsychotic medication typically leads to improvement. Further research is warranted on this topic.

Fields of Study & Subjects

Methemoglobinemia and Tumor Lysis Syndrome Nitric Oxide and Endothelin Effects Heavy Metal Exposure and Toxicity

Publication details

Journal / source
Clinical Psychopharmacology and Neuroscience
Publisher
Korean College of Neuropsychopharmacology
Volume
24
Issue
2
Pages
252–276
Publication date
6 April 2026
Language
EN