Roadmap for Condensates in Cell Biology

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Authors: Dilimulati Aierken, Sebastian Aland, Stefano Bo, Steven Boeynaems, Danfeng Cai, Serena Carra, Lindsay B. Case, Hue Sun Chan, Jorge R. Espinosa, Trevor K. GrandPre, Alexander Y. Grosberg, Ivar S. Haugerud
+29 more William M. Jacobs, Jerelle A. Joseph, Frank Jülicher, Kurt Kremer, Guido L. A. Kusters, Liedewij Laan, Keren Lasker, Katrin S. Laxhuber, Hyun Lee, Kathy F. Liu, Dimple Notani, Yicheng Qiang, Paul Robustelli, Leonor Saiz, Saleh, Omar A., Helmut Schießel, Jeremy D. Schmit, Meng Shen, Krishna Shrinivas, Antonia Statt, Andrés R. Tejedor, Tatjana Trcek, Christoph A. Weber, Stephanie C. Weber, Ned S. Wingreen, Huaiying Zhang, Yaojun Zhang, Huan Xiang Zhou, David Zwicker
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Abstract

Biomolecular condensates govern essential cellular processes yet elude description by traditional equilibrium models. This roadmap, distilled from structured discussions at a workshop and reflecting the consensus of its participants, clarifies key concepts for researchers, funding bodies, and journals. After unifying terminology that often separates disciplines, we outline the core physics of condensate formation, review their biological roles, and identify outstanding challenges in nonequilibrium theory, multiscale simulation, and quantitative in-cell measurements. We close with a forward-looking outlook to guide coordinated efforts toward predictive, experimentally anchored understanding and control of biomolecular condensates.

Fields of Study & Subjects

Protein Structure and Dynamics Gene Regulatory Network Analysis RNA Research and Splicing

Publication details

Journal / source
arXiv (Cornell University)
Publication date
7 January 2026
Document type
Preprint