Kontrolle der Aktin Dynamik durch lokale Phasenseparation VASPs
Abstract
Polymerization and disassembly of polar actin filaments enable cellular shape adaptation and motility. However, the interplay of actin-binding proteins controlling these dynamics is poorly understood. In this thesis, a mechanism is presented by which phase separation and localization of VASP at lipid bilayers enable reconstitution of the assembly of bundled actin filaments. The phase-separated VASP bound to actin bundles controls the disassembly rate by cofilin, leading to treadmilling of actin bundles and formation of highly ordered actin networks.
Fields of Study & Subjects
Cellular Mechanics and Interactions
Lipid Membrane Structure and Behavior
Advanced Materials and Mechanics
Publication details
- Journal / source
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)
- Publication date
- 8 January 2026
- Language
- EN
- Document type
- Thesis