Mitochondrien ermöglichen die Aufnahme von Calcium in das ER via SYNJ2BP-SERCA Kontakten in Neuronen

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Authors: Simone Wanderoy Blemings
Cited by: 0

Abstract

Recently, the mitochondria situated SYNJ2BP has been identified as a mitochondrion – ER tether. However, the exact mechanism by which SYNJ2BP impacts ER Ca2+ still remains to be elucidated. Here, I report that SYNJ2BP regulates the uptake of Ca2+ into the ER. In concert with the neuron-enriched SYNJ2a, SYNJ2BP forms a tether with SERCA. Additionally, neurons with reduced availability of SYNJ2BP are less viable than control neurons. The result from this project emphasize the importance of the threeway complex in neurons.

Fields of Study & Subjects

Mitochondrial Function and Pathology Alzheimer's disease research and treatments Neuroscience and Neuropharmacology Research

Publication details

Journal / source
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)
Publication date
8 January 2026
Language
EN
Document type
Thesis