[HDR] Naviguer à bord de l’interdisciplinarité, à la confluence de l’ingénierie et de la biologie : Développement de dispositifs microfluidiques biomimétiques

This Habilitation to Supervise Research (HDR) report presents a scientific journey built at the crossroads of physics, microtechnology, and life sciences. My work is driven by a central objective: to design and exploit microfluidic and biomimetic devices to model, analyze, and interact with living systems at the microscale. Initially focused on Terahertz spectroscopy for the characterization of biological media, my research progressively evolved toward the development of organ-on-chip platforms and opto-fluidic systems dedicated to cellular biology and translational medicine.Conducted within the BioMEMS group at IEMN, this research embodies a strongly interdisciplinary approach, bridging engineering, biophysics, and experimental biology. It has led to the creation of innovative in vitro models for studying metastasis, diabetes, cellular transfection, and drug-device interactions. Beyond scientific achievements, this HDR reflects a vision of research that combines experimental rigor, technological creativity, and openness to clinical and societal applications — contributing to the structuring of a new field of inquiry: technologies for life and health.