[Advances of neutrophil extracellular traps in diabetic wounds].

PubMed 2026

Authors: Zhihong Guo, Yingying Chen, Dewu Liu
Cited by: 0

Abstract

Diabetic wounds, recognized as the most prevalent chronic, difficult-to-heal wounds, severely impair patients' quality of life and impose a substantial socio-economic burden. The wounds' pathological manifestation is characterized by excessive inflammatory responses, with neutrophil extracellular trap (NET) identified as a core driver of this dysregulation. This review systematically elaborates the molecular mechanisms of NET in diabetic wound pathology. Crucially, it reveals NET's value, serving as both a novel therapeutic target and a biomarker for prognostic assessment, thereby furnishing the theoretical foundation and translational guidance necessary to overcome the current dilemmas in diagnosis and treatment.

Fields of Study & Subjects

Neutrophil Myeloperoxidase and Oxidative Mechanisms Wound Healing and Treatments Autoimmune and Inflammatory Disorders

Publication details

Journal / source
PubMed
Volume
42
Issue
1
Pages
60–66
Publication date
1 January 2026
Language
ZH