[Construction, screening and functional characterization of a mammalian cell-displayed antibody library targeting Tim-3].

PubMed 2026

Authors: Lin Du, Guoxian Li, Chunxiao Du, Junrui Chen, Yuxiang Li, Zhiding Wang, Ge Li, Gencheng Han
Cited by: 0

Abstract

cells proliferation more effectively than the parental Tim-3 antibody. Conclusion A novel humanized Tim-3 antibody (No.1) with enhanced affinity and capacity to upregulate multiple cytokine expressions in both human and murine cell lines was obtained via a computer-aided molecular design platform and mammalian cell antibody display library technology.

Fields of Study & Subjects

Monoclonal and Polyclonal Antibodies Research T-cell and B-cell Immunology Cancer Immunotherapy and Biomarkers

Publication details

Journal / source
PubMed
Volume
42
Issue
1
Pages
52–59
Publication date
1 January 2026
Language
ZH