The Science of Pseudoaccommodation and Its Therapeutic Potential

Jakub Poliński,1,2 Dorota Walasik-Szemplińska,2 Janusz Skrzypecki2– 4 1Department of Ophthalmology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland; 2Sensor Cliniq, Warsaw, Poland; 3Mediq Cliniq, Legionowo, Poland; 4Department of Experimental Physiology and Pathophysiology, Medical University of Warsaw, Warsaw, PolandCorrespondence: Janusz Skrzypecki, Department of Experimental Physiology and Pathophysiology, Medical University of Warsaw, Banacha 1B, Warsaw, 02-097, Poland, Tel +48 22 116 6195, Fax +48 22 57 20 734, Email jskrzypecki@wum.edu.plAbstract: Pseudoaccommodation is a critical yet often underappreciated factor influencing visual outcomes after cataract surgery. Despite the irreversible loss of true accommodation due to presbyopia or intraocular lens (IOL) implantation, many patients retain meaningful near and intermediate vision—a phenomenon driven by optical and anatomical contributors such as pupil size, astigmatism, and higher-order aberrations. This functional benefit, known as pseudoaccommodation, can be further enhanced pharmacologically through miotic agents like pilocarpine or surgically via multifocal and extended depth-of-field (EDOF) IOLs. However, these strategies may come with trade-offs, including dysphotopsia and reduced contrast sensitivity. Understanding the mechanisms and limitations of pseudoaccommodation is essential for optimizing IOL selection, managing patient expectations, and improving satisfaction. This comprehensive review synthesizes the current evidence on the anatomical, optical, pharmacologic, and technological factors that contribute to pseudoaccommodation, offering practical guidance for counseling both phakic and pseudophakic presbyopic patients.Keywords: presbyopia, optical system, pseudoaccommodation