Effect of Venlafaxine on Inflammatory Level in Patients with Depression

Huan Zhang,1 Na Huang,2 Xinxin Ma,1 Yanan Liu3 1Department of Psychiatry, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Central Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Huan Zhang, Department of Psychiatry, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157, Xiwu Road, Xi’an, Shaanxi, 710004, People’s Republic of China, Tel +86-029-87679349, Fax +86-029-87679349, Email zhanghuan_huanz@163.comBackground: Venlafaxine is widely applied to treat depression. Herein, we further explore the effect of venlafaxine on inflammatory level in patients with depression.Methods: Retrospectively, the medical data of patients (from January 2020 to February 2023, following up for 1 year) with depression (n=134) and without depression (health group, n=63) were collected. According to different treatment methods, patients with depression were categorized into the venlafaxine group (n=71) and the fluoxetine group (n=63). After treatment 8 weeks and 1 year, the baseline characteristics, therapeutic effect, inflammatory level and adverse events were analyzed.Results: After treatment 8 weeks and 1 year, there were significant improvements about depression and inflammatory level in venlafaxine group and fluoxetine group (P